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Biography Biography

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Dr. Raymond Chan has been conducting research actively in neuropsychology and mental health, particularly in understanding cognitive deficitsin patients with schizophrenia and its underlying psychopathology. He is now a Distinguished Professor of Neuropsychology and Applied Cognitive Neuroscience at the Institute of Psychology of the Chinese Academy of Sciences. He is also thehonorary director for research at the Institute of Mental Health, Castle Peak Hospital (Hong Kong) and honorary director for the Translational Neuropsychology and Applied Cognitive Neuroscience Lab at the Shanghai Mental Health Centre. His research record has earned him the Distinguished Young Scientist Award from the National Science Foundation China, Young Investigator Award from NARSAD, and the Distinguished Griffith Visiting Researcher, and elected fellow of the Association for Psychological Science.He is the Regional Representative for Asia for the International Neuropsychological Society. He holds numerous funds from various funding agents, including the National Science Foundation of China, the Chinese Academy of Sciences, the Ministry of Science and Technology of China, NARSAD, and the Smart Futures Fund (QLD), National and International Research Alliances Program.Dr. Chan has published over 300 scientific peer-reviewed articles and 6 book chapters dealing with schizophrenia research and traumatic brain injury, including New England Journal of Medicine, JAMA Psychiatry, Molecular Psychiatry, Neuroscience and Biobehavioral Reviews, Schizophrenia Bulletinetc. He is currentlyserving at the co-editor-in-chief of "PsyCh Journal" and the editorial boards of "Schizophrenia Bulletin", "Neuropsychology", "Clinical Rehabilitation" , "Cognitive Neuropsychiatry", and "Neuropsychological Rehabilitation" and four local professional journals.


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Raymond C K Chan, Ph.D. (HK)

Professor of Neuropsychology and Applied Cognitive Neuroscience

Neuropsychology and Applied Cognitive Neuroscience Laboratory

Key Laboratory of Mental Health

Institute of Psychology

Chinese Academy of Sciences




Email: or


Research Interest

l   Neuropsychopathology of psychotic disorders and identification of endophenotypes/biomarkers for these clinical groups such as schizophrenia and bipolar disorders

l   Study of neuropsychological performances along the continuum of psychosis

l   Application of social cognitive neuroscience (social psychology, cognitive sciences, neuropsychology) to the development of clinical assessment and intervention for psychotic disorders and at-risk individuals

l   Measurement issues in clinical practice (e.g., development and validation of ecological valid test of neuropsychological performance, and articulating the laboratory-based test results to everyday life performance)

l   Developmental psychopathology


Selected Publications

Chan, R. C. K., Chen, E. Y. H., & Law, C. W. (2006). Specific executive dysfunction in patients with first-episode medication-naïve schizophrenia. Schizophrenia Research, 82(1), 51-64


Chan, R. C. K., Gottesman, I. I. (2008). Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star? Neuroscience and Biobehavioral Reviews, 32, 957-971.


Chan, R. C. K., Shum, D., Toulopoulou, T., & Chen, E. (2008). Assessment of executive functions: Review of instruments and identification of critical issues. Archives of Clinical Neuropsychology, 23(2), 201-216.


Chan, R. C. K.*, Di, X., McAlonan, G. M., Gong, Q. (2011). Brain anatomical abnormalities in high risk individuals, first-episode and chronic schizophrenia: an activation likelihood estimation meta-analysis of illness progress. Schizophrenia Bulletin, 37(1), 177-188.


Zhao, Q., Li, Z., Huang, J., Yan, C., Dazzan, P., Pantelis, C., Cheung, E. F. C., Lui, S. S. Y., Chan, R. C. K.*.(2014). Neurological soft signs are not "soft" in brain structure and functional networks: Evidence from ALE meta-analysis. Schizophrenia Bulletin, 40(3): 626-641.


Xie, W. Z., Yan, C., Ying, X. Y., Zhu, S. Y., Shi, H. S., Wang, Y., Cheung, E. F. C., Chan R. C. K.* (2014). Domain-specific deficits towards social affective but not monetary incentives in social anhedonia. Scientific Reports, 4:4056 DOI:10.1038/srep04056


Chan, R. C. K.*,Dai, S., Lui, S. S. Y., Ho, K. K. Y., Hung, K. S. Y., Wang, Y., Geng, F. L., Li, Z., Cheung, E. F. C. (2015). Re-visiting the nature and relationships between neurological signs and neurocognitive function in first-episode schizophrenia: An invariance model across time. Scientific Reports, 5:11850 | DOI: 10.1038/srep11850


Li, Z., Lui, S. S. Y., Geng, F. L., Li, Y., Li, W. X., Wang, C. Y., Tan, S. P., Cheung, E. F. C., Kring, A. M., Chan, R. C. K.* (2015). Experiential pleasure deficits in different stages of schizophrenia. Schizophrenia Research, 166(1-3), 98-103.


Li, Z., Yan, C., Xie, W. Z., Li, K., Zeng, Y. W., Jin, Z., Cheung, E. F. C., Chan, R. C. K.* (2015). Anticipatory pleasure predicts effective connectivity in the mesolimbic system. Frontiers in Behavioral Neuroscience,9:217. doi: 10.3389/fnbeh.2015.00217


Wang, Y., Yan, Chao, Yin, D. Z., Fan, M. X., Cheung, E. F. C., Pantelis C., Chan, R. C. K.* (2015). Neurobiological changes of schizotypy: evidence from both volume based morphometric analysis and resting-state functional connectivity. Schizophrenia Bulletin, 41 (suppl 2): S444-S454


Li, X., Li, Z., Li, K., Zeng, Y. W., Shi, H. S., Xie, W. L., Yang, Z. Y., Lui, S. S. Y., Cheung, E. F. C., Leung, A. W. S., Chan, R. C. K.* (2016).          The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia. Scientific Reports, 6:35481 | DOI: 10.1038/srep35481


Lui, S. S. Y., Liu, A. C. Y., Chui, W. W. H., Li, Z., Geng, F. L., Wang, Y., Heerey, E. A., Cheung, E. F. C.,Chan, R. C. K.* (2016). The nature of anhedonia and avolition in patients with first-episode schizophrenia. Psychological Medicine, 46,437-447. doi:10.1017/S0033291715001968   


Wang, Y., Liu, W. H., Wei, X. H., Jiang, X. Q., Geng, F. L., Zou, L. Q., Lui, S. S. Y., Cheung, E. F. C., Pantelis, C.,Chan, R. C. K.* (2016). Altered corticostriatal functional connectivity in individuals with high social anhedonia. Psychological Medicine, 46, 125-135.  doi:10.1017/S0033291715001592


Xu, T#., Wang, Y.#, Li, Z.#, Huang, J., Lui, S. S. Y., Tan, S. P., Yu, X., Cheung, E. F. C., He, M. G., Ott, J., Gur, R. E., Gur, R. C., Chan, R. C. K.* (2016). Heritability and familiality of neurological soft signs: Evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives. Psychological Medicine,46, 117-123.  doi:10.1017/S0033291715001580


Chan, R. C. K. *, Gooding, D. C.*, Shi, H. S., Geng, F. L., Xie, D. J., Yang, Z. Y., Liu, W. H., Wang, Y., Yan, C., Shi, C., Lui, S. S. Y., Cheung, E. F. C. (2016). Evidence of structural invariance across three groups of Meehlian schizotypes. npj Schizophrenia, 2, 16016, doi:10.1038/npjschz.2016.16


Chan, R. C. K*., Xie, W., Geng, F. L., Wang, Y., Lui, S. S. Y., Wang, C. Y., Yu, X., Cheung, E. F. C., Rosenthal, R. (2016). Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders, Schizophrenia Bulletin, 42(3), 560-570. doi:10.1093/schbul/sbv196


Tang, J.#, Fan, Y.#, Li, H.#, Xiang, Q., Zhang, D. F., Li, Z. C., He, Y., Liao, Y. H., Wang, Y., He, F., Zhang, F., Shugart, Y. Y., Liu, C., Tang Y., Chan, R. C. K..*, Wang, C. Y.*, Yao, Y. G.*, Chen, X*. (2017). Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia. Journal of Genetics and Genomics, 44, 295-306

Wang, Y. Y., Wang, Y.*, Zou, Y. M., Ni, K., Tian, X., Sun, H. W., Lui, S. S. Y., Cheung, E. F. C., Suckling, J., Chan, R. C. K.*(2018). Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder. Schizophrenia Research,197, 349-356.


Xie, D. J.#, Lui, S. S. Y.#, Geng, F. L., Yang, Z. Y., Zou, Y. M., Li, Y., Yeug, H. K. H., Cheung, E. F. C., Heerey, E. A., Chan, R. C. K. * (2018). Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypyal individuals. Psychological Medicine, 48(9), 1474-1483. DOI 10.1017/S0033291717002926

Docherty, A.R.*, Fonseca-Pedrero, E., Debbane, M., Chan, R.C.K., Linscott, R.J., Jonas, K.G., Cicero, D.C., Green, M.J., Simms, L.J., Mason, O., Watson, D., Ettinger, U., Waszczuk, M., Rapp, A., Grant, P., Kotov, R., DeYoung, C.G., Ruggero, C.J., Eaton, N.R., Krueger, R.F., Patrick, C., Hopwood, C., O'Neill, F.A., Zald, D.H., Conway, C.C., Adkins, D.E., Waldman, I.D., van Os, J., Sullivan, P.F., Anderson, J.S., Shabalin, A.A., Sponheim, S.R., Taylor, S.F., Grazioplene, R.G., Bacanu, S.A., Bigdeli, T.B., Haenschel, C., Malaspina, D., Gooding, D.C., Nicodemus, K., Schultze-Lutter, F., Barrantes-Vidal, N., Mohr, C., Carpenter, W. T., Cohen, A.S. (2018). Enhancing psychosis-spectrum nosology with an international data sharing initiative. Schizophrenia Bulletin, 44 (Suppl 2), S460-S467.


Li, Z.#, Huang#, J., Xu, T.#, Wang, Y., Li, K., Zeng, Y. W., Lui, S. S. Y., Cheung, E. F. C., Jin, Z., Dazzan, P., Glahn, D. C.,Chan, R. C. K.* (2018). Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study. Human Brain Mapping, 39(3), 143-1448. DOI: 10.1002/hbm.23935


Yang, Z. Y., Xie,D. J., Zou, Y. M., Wang, Y., Li, Y., Shi, H. S., Zhang, R. T., Li, W. X., Cheung, E. F. C., Kring, A. M., Chan, R. C. K.* (2018). Prospection deficits in schizophrenia: Evidence from clinical and subclinical samples. Journal of Abnormal Psychology, 127(7), 710-721.


Zhou, H. Y., Cai, X. L., Weigl, M., Bang, P., Cheung, E. F. C., Chan, R. C. K.* (2018). Multisensory temporal binding window in autism spectrum disorders and schizophrenia spectrum disorders: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 86, 66-76.


Zou, L. Q., Zhou, H. Y., Lui, S. S. Y., Wang, Y., Wang, Y., Gan, J., Zhu, X. Z., Cheung, E. F. C., Chan, R. C. K. * (2018). Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 83, 137- 141.


Zou, L. Q., Zhou, H. Y., Zhuang, Y., van Hartevelt, T. J., Lui, S. S. Y., Cheung, E. F. C., Møller, A., Kringerlback, M. L., Chan, R. C. K. * (2018). Neural responses during the anticipation and rceipt of olfactory reward and punishment in human. Neuropsychologia, 111, 172–179


Wang, Y. M., Zou, L. Q., Xie, W. L., Yang, Z. Y., Zhu, X. Z., Cheung, E. F. C., Sørensen, T. A., Møller, A., Chan, R. C. K. *(2019). Altered functional connectivity of the default mode network in patients with schizo-obsessive comorbidity: A comparison between schizophrenia and obsessive-compulsive disorder. Schizophrenia Bulletin, 4(1), 199-210.

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