Raymond C K Chan, Ph.D. (HK)

Professor of Neuropsychology and Applied Cognitive Neuroscience

Neuropsychology and Applied Cognitive Neuroscience Laboratory

Key Laboratory of Mental Health

Institute of Psychology

Chinese Academy of Sciences




Email: or


Research Interest

l   Neuropsychopathology of psychotic disorders and identification of endophenotypes/biomarkers for these clinical groups such as schizophrenia and bipolar disorders

l   Study of neuropsychological performances along the continuum of psychosis

l   Application of social cognitive neuroscience (social psychology, cognitive sciences, neuropsychology) to the development of clinical assessment and intervention for psychotic disorders and at-risk individuals

l   Measurement issues in clinical practice (e.g., development and validation of ecological valid test of neuropsychological performance, and articulating the laboratory-based test results to everyday life performance)

l   Developmental psychopathology


Editorial boards

Clinical Rehabilitation

Cognitive Neuropsychiatry

Neuropsychological Rehabilitation


PsyCh Journal

Psychiatry Research

Schizophrenia Bulletin

Scientific Reports


Selected Publications

Chan, R. C. K., Chen, E. Y. H., & Law, C. W. (2006). Specific executive dysfunction in patients with first-episode medication-naïve schizophrenia. Schizophrenia Research, 82(1), 51-64


Chan, R. C. K., Gottesman, I. I. (2008). Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star? Neuroscience and Biobehavioral Reviews, 32, 957-971.


Chan, R. C. K., Shum, D., Toulopoulou, T., & Chen, E. (2008). Assessment of executive functions: Review of instruments and identification of critical issues. Archives of Clinical Neuropsychology, 23(2), 201-216.


Chan, R. C. K.*, Di, X., McAlonan, G. M., Gong, Q. (2011). Brain anatomical abnormalities in high risk individuals, first-episode and chronic schizophrenia: an activation likelihood estimation meta-analysis of illness progress. Schizophrenia Bulletin, 37(1), 177-188.


Zhao, Q., Li, Z., Huang, J., Yan, C., Dazzan, P., Pantelis, C., Cheung, E. F. C., Lui, S. S. Y., Chan, R. C. K.*. (2014). Neurological soft signs are not "soft" in brain structure and functional networks: Evidence from ALE meta-analysis. Schizophrenia Bulletin, 40(3): 626-641.


Xie, W. Z., Yan, C., Ying, X. Y., Zhu, S. Y., Shi, H. S., Wang, Y., Cheung, E. F. C., Chan R. C. K.* (2014). Domain-specific deficits towards social affective but not monetary incentives in social anhedonia. Scientific Reports, 4:4056 DOI:10.1038/srep04056


Chan, R. C. K.*,Dai, S., Lui, S. S. Y., Ho, K. K. Y., Hung, K. S. Y., Wang, Y., Geng, F. L., Li, Z., Cheung, E. F. C. (2015). Re-visiting the nature and relationships between neurological signs and neurocognitive function in first-episode schizophrenia: An invariance model across time. Scientific Reports, 5:11850 | DOI: 10.1038/srep11850


Li, Z., Lui, S. S. Y., Geng, F. L., Li, Y., Li, W. X., Wang, C. Y., Tan, S. P., Cheung, E. F. C., Kring, A. M., Chan, R. C. K.* (2015). Experiential pleasure deficits in different stages of schizophrenia. Schizophrenia Research, 166(1-3), 98-103.


Li, Z., Yan, C., Xie, W. Z., Li, K., Zeng, Y. W., Jin, Z., Cheung, E. F. C., Chan, R. C. K.* (2015). Anticipatory pleasure predicts effective connectivity in the mesolimbic system. Frontiers in Behavioral Neuroscience, 9:217. doi: 10.3389/fnbeh.2015.00217


Wang, Y., Yan, Chao, Yin, D. Z., Fan, M. X., Cheung, E. F. C., Pantelis C., Chan, R. C. K.* (2015). Neurobiological changes of schizotypy: evidence from both volume based morphometric analysis and resting-state functional connectivity. Schizophrenia Bulletin, 41 (suppl 2): S444-S454


Lui, S. S. Y., Liu, A. C. Y., Chui, W. W. H., Li, Z., Geng, F. L., Wang, Y., Heerey, E. A., Cheung, E. F. C.,Chan, R. C. K.* (2016). The nature of anhedonia and avolition in patients with first-episode schizophrenia. Psychological Medicine, 46,437-447. doi:10.1017/S0033291715001968   


Wang, Y., Liu, W. H., Wei, X. H., Jiang, X. Q., Geng, F. L., Zou, L. Q., Lui, S. S. Y., Cheung, E. F. C., Pantelis, C., Chan, R. C. K.* (2016). Altered corticostriatal functional connectivity in individuals with high social anhedonia. Psychological Medicine, 46, 125-135.  doi:10.1017/S0033291715001592


Xu, T#., Wang, Y.#, Li, Z.#, Huang, J., Lui, S. S. Y., Tan, S. P., Yu, X., Cheung, E. F. C., He, M. G., Ott, J., Gur, R. E., Gur, R. C., Chan, R. C. K.* (2016). Heritability and familiality of neurological soft signs: Evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives. Psychological Medicine,46, 117-123.  doi:10.1017/S0033291715001580


Chan, R. C. K. *, Gooding, D. C.*, Shi, H. S., Geng, F. L., Xie, D. J., Yang, Z. Y., Liu, W. H., Wang, Y., Yan, C., Shi, C., Lui, S. S. Y., Cheung, E. F. C. (2016). Evidence of structural invariance across three groups of Meehlian schizotypes. npj Schizophrenia, 2, 16016, doi:10.1038/npjschz.2016.16


Chan, R. C. K*., Xie, W., Geng, F. L., Wang, Y., Lui, S. S. Y., Wang, C. Y., Yu, X., Cheung, E. F. C., Rosenthal, R. (2016). Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders, Schizophrenia Bulletin, 42(3), 560-570. doi:10.1093/schbul/sbv196

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