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Raymond C K Chan, Ph.D. (HK)

Professor of Neuropsychology and Applied Cognitive Neuroscience

Neuropsychology and Applied Cognitive Neuroscience Laboratory

Key Laboratory of Mental Health

Institute of Psychology

Chinese Academy of Sciences

Beijing100101

China

 

Email: rckchan@psych.ac.cn or rckchan2003@yahoo.com.hk

 

Research Interest

l   Neuropsychopathology of psychotic disorders and identification of endophenotypes/biomarkers for these clinical groups such as schizophrenia and bipolar disorders

l   Study of neuropsychological performances along the continuum of psychosis

l   Application of social cognitive neuroscience (social psychology, cognitive sciences, neuropsychology) to the development of clinical assessment and intervention for psychotic disorders and at-risk individuals

l   Measurement issues in clinical practice (e.g., development and validation of ecological valid test of neuropsychological performance, and articulating the laboratory-based test results to everyday life performance)

l   Developmental psychopathology

 

Selected Publications

  • Chan, R. C. K., Chen, E. Y. H., & Law, C. W. (2006). Specific executive dysfunction in patients with first-episode medication-naïve schizophrenia. Schizophrenia Research, 82(1), 51-64.
  • Chan, R. C. K., Gottesman, I. I. (2008). Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star? Neuroscience and Biobehavioral Reviews, 32, 957-971.
  • Chan, R. C. K., Shum, D., Toulopoulou, T., & Chen, E. (2008). Assessment of executive functions: Review of instruments and identification of critical issues. Archives of Clinical Neuropsychology, 23(2), 201-216.
  • Chan, R. C. K.*, Di, X., McAlonan, G. M., Gong, Q. (2011). Brain anatomical abnormalities in high risk individuals, first-episode and chronic schizophrenia: an activation likelihood estimation meta-analysis of illness progress. Schizophrenia Bulletin, 37(1), 177-188.
  • Zhao, Q., Li, Z., Huang, J., Yan, C., Dazzan, P., Pantelis, C., Cheung, E. F. C., Lui, S. S. Y., Chan, R. C. K.*.(2014). Neurological soft signs are not "soft" in brain structure and functional networks: Evidence from ALE meta-analysis. Schizophrenia Bulletin, 40(3): 626-641.
  • Chan, R. C. K.*,Dai, S., Lui, S. S. Y., Ho, K. K. Y., Hung, K. S. Y., Wang, Y., Geng, F. L., Li, Z., Cheung, E. F. C. (2015). Re-visiting the nature and relationships between neurological signs and neurocognitive function in first-episode schizophrenia: An invariance model across time. Scientific Reports, 5:11850 | DOI: 10.1038/srep11850
  • Wang, Y., Yan, Chao, Yin, D. Z., Fan, M. X., Cheung, E. F. C., Pantelis C., Chan, R. C. K.* (2015). Neurobiological changes of schizotypy: evidence from both volume based morphometric analysis and resting-state functional connectivity. Schizophrenia Bulletin, 41 (suppl 2): S444-S454
  • Lui, S. S. Y., Liu, A. C. Y., Chui, W. W. H., Li, Z., Geng, F. L., Wang, Y., Heerey, E. A., Cheung, E. F. C.,Chan, R. C. K.* (2016). The nature of anhedonia and avolition in patients with first-episode schizophrenia. Psychological Medicine, 46，437-447. doi:10.1017/S0033291715001968   
  • Wang, Y., Liu, W. H., Wei, X. H., Jiang, X. Q., Geng, F. L., Zou, L. Q., Lui, S. S. Y., Cheung, E. F. C., Pantelis, C.,Chan, R. C. K.* (2016). Altered corticostriatal functional connectivity in individuals with high social anhedonia. Psychological Medicine, 46, 125-135.  doi:10.1017/S0033291715001592
  • Xu, T#., Wang, Y.#, Li, Z.#, Huang, J., Lui, S. S. Y., Tan, S. P., Yu, X., Cheung, E. F. C., He, M. G., Ott, J., Gur, R. E., Gur, R. C., Chan, R. C. K.* (2016). Heritability and familiality of neurological soft signs: Evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives. Psychological Medicine,46, 117-123.  doi:10.1017/S0033291715001580
  • Chan, R. C. K. *, Gooding, D. C.*, Shi, H. S., Geng, F. L., Xie, D. J., Yang, Z. Y., Liu, W. H., Wang, Y., Yan, C., Shi, C., Lui, S. S. Y., Cheung, E. F. C. (2016). Evidence of structural invariance across three groups of Meehlian schizotypes. npj Schizophrenia, 2, 16016, doi:10.1038/npjschz.2016.16
  • Chan, R. C. K*., Xie, W., Geng, F. L., Wang, Y., Lui, S. S. Y., Wang, C. Y., Yu, X., Cheung, E. F. C., Rosenthal, R. (2016). Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders, Schizophrenia Bulletin, 42(3), 560-570. doi:10.1093/schbul/sbv196
  • Wang, Y. Y., Wang, Y.*, Zou, Y. M., Ni, K., Tian, X., Sun, H. W., Lui, S. S. Y., Cheung, E. F. C., Suckling, J., Chan, R. C. K.*(2018). Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder. Schizophrenia Research,197, 349-356.  https://doi.org/10.1016/j.schres.2017.11.003
  • Xie, D. J.#, Lui, S. S. Y.#, Geng, F. L., Yang, Z. Y., Zou, Y. M., Li, Y., Yeug, H. K. H., Cheung, E. F. C., Heerey, E. A., Chan, R. C. K. * (2018). Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypyal individuals. Psychological Medicine, 48(9), 1474-1483. DOI 10.1017/S0033291717002926
  • Docherty, A.R.*, Fonseca-Pedrero, E., Debbane, M., Chan, R.C.K., Linscott, R.J., Jonas, K.G., Cicero, D.C., Green, M.J., Simms, L.J., Mason, O., Watson, D., Ettinger, U., Waszczuk, M., Rapp, A., Grant, P., Kotov, R., DeYoung, C.G., Ruggero, C.J., Eaton, N.R., Krueger, R.F., Patrick, C., Hopwood, C., O'Neill, F.A., Zald, D.H., Conway, C.C., Adkins, D.E., Waldman, I.D., van Os, J., Sullivan, P.F., Anderson, J.S., Shabalin, A.A., Sponheim, S.R., Taylor, S.F., Grazioplene, R.G., Bacanu, S.A., Bigdeli, T.B., Haenschel, C., Malaspina, D., Gooding, D.C., Nicodemus, K., Schultze-Lutter, F., Barrantes-Vidal, N., Mohr, C., Carpenter, W. T., Cohen, A.S. (2018). Enhancing psychosis-spectrum nosology with an international data sharing initiative. Schizophrenia Bulletin, 44 (Suppl 2), S460-S467.
  • Li, Z.#, Huang#, J., Xu, T.#, Wang, Y., Li, K., Zeng, Y. W., Lui, S. S. Y., Cheung, E. F. C., Jin, Z., Dazzan, P., Glahn, D. C.,Chan, R. C. K.* (2018). Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study. Human Brain Mapping, 39(3), 143-1448. DOI: 10.1002/hbm.23935
  • Yang, Z. Y., Xie,D. J., Zou, Y. M., Wang, Y., Li, Y., Shi, H. S., Zhang, R. T., Li, W. X., Cheung, E. F. C., Kring, A. M., Chan, R. C. K.* (2018). Prospection deficits in schizophrenia: Evidence from clinical and subclinical samples. Journal of Abnormal Psychology, 127(7), 710-721.
  • Zhou, H. Y., Cai, X. L., Weigl, M., Bang, P., Cheung, E. F. C., Chan, R. C. K.* (2018). Multisensory temporal binding window in autism spectrum disorders and schizophrenia spectrum disorders: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 86, 66-76.
  • Wang, Y. M., Zou, L. Q., Xie, W. L., Yang, Z. Y., Zhu, X. Z., Cheung, E. F. C., Sørensen, T. A., Møller, A., Chan, R. C. K. *(2019). Altered functional connectivity of the default mode network in patients with schizo-obsessive comorbidity: A comparison between schizophrenia and obsessive-compulsive disorder. Schizophrenia Bulletin, 4(1), 199-210.
  • Li, Z., Wang, Y., Yan, C., Cheung, E. F. C., Docherty, A. R., Sham, P. C., Gur, R. E., Gur, R. C.,Chan, R. C. K. * (2019). Inheritance of neural substrates for motivation and pleasure experience. Psychological Science, 30(8),1205-1217. DOI: 10.1177/0956797619859340
  • Wang, Y. Y., Ge, M. H., Zhu, G. H., Jiang, N. Z., Wang, G. Z., Lv, S. X., Zhang, Q., Guo, J. N., Tian, X., Lui, S. S. Y., Cheung, E. F. C., Heerey, E. A., Sun, H. W.*, Chan, R. C. K. * (2020). Emotion-behaviour decoupling in individuals with schizophrenia, bipolar disorder and major depressive disorder. Journal of Abnormal Psychology, 129(4), 331–342. https://doi.org/10.1037/abn0000499
  • Zhou, H. Y., Yang, H. X., Gong, J. B., Cheung, E. F. C., Gooding. D. C., Park, S. H., Chan, R. C. K.* (2019). Revisiting the overlap between autistic and schizotypal traits in the non-clinical population using meta-analysis and network analysis. Schizophrenia Research, 212, 6-14.  DOI:10.1016/j.schres.2019.07.050
  • Kong, L., Herold, C. J., Cheung, E. F. C., Chan, R. C. K.*, Schröder, J. (2020). Neurological soft signs and brain network abnormalities in schizophrenia. Schizophrenia Bulletin, 46(3), 562–571.
  • Wang, Y., Wang, Y. M., Lui, S. S. Y., Chan, R. C. K.* (2020). Clinical implication of brain asymmetries in psychiatric disorders. Biological Psychiatry, 87(12), 1014-1016.
  • Wang, Y. M., Cai, X. L., Zhang, R. T., Zhang,Y. J., Zhou, H. Y., Wang, Y., Wang, Y., Huang, J., Wang, Y. Y., Cheung, E. F. C., Chan, R. C. K.* (2020). Altered brain structural and functional connectivity in schizotypy. Psychological Medicine, DOI: https://doi.org/10.1017/S0033291720002445
  • Wang, Y. M., Yang, Z. Y., Cai, X. L., Zhou, H. Y., Zhang, R. T., Yang, H. X., Liang, Y. S., Zhu, X. Z., Mardsen, K. H., Sørensen, T. A., Møller, A., Wang, Z., Cheung, E. F. C., Chan, R. C. K.* (2020). Identifying schizo-obsessive comorbidity by tract-based spatial statistics and probabilistic tractography. Schizophrenia Bulletin,46(2), 442-453. DOI:10.1093/schbul/sbz073
  • Cai, X. L., Wang, Y. M., Wang, Y., Zhou, H. Y., Huang, J., Wang, Y., Lui, S. S. Y., Møller, A., Hung, K. S. Y., Mak, H. K. F., Sham, P. C., Cheung, E. F. C., Chan, R. C. K.* (2021). Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia. Schizophrenia Bulletin, 47(5), 1452–1462, https://doi.org/10.1093/schbul/sbaa200
  • Zhou, H. Y., Cui, X. L., Yang, B. R., Shi, L. J., Luo, X. R., Cheung, E. F. C., Lui, S. S. Y., Chan, R. C. K.* (2021). Audiovisual temporal processing in children and adolescents with schizophrenia and autism: Evidence from simultaneity judgement tasks and eye-tracking data. Clinical Psychological Science, https://doi.org/10.1177/216770262110315
  • Zhou, H. Y., Wang, Y. M., Zhang, R. T., Cheung, E. F. C., Pantelis, C., Chan, R. C. K.* (2021). Neural correlates of audiovisual temporal binding window in individuals with schizotypal and autistic traits: Evidence from resting-state functional connectivity. Autism Research, 14: 668–680. DOI: 10.1002/aur.2456 
附件: Full publication list 12_10_21.pdf (1,791.4k)